Cannabinoids are natural occurring compounds found in our body that regulate communication between cells throughout the central nervous system and immune system to promote a general state of wellbeing. CBD also:
The skin has the highest amount and concentration of CB2 receptors in the body. When applied topically, CBD (a more powerful antioxidant than vitamins E and C)8 has many benefits and can repair skin damage from free-radicals like UV rays and environmental pollutants. Because of its anti-inflammatory properties and being such a rich source of fatty acids and other skin-healthy nutrients, CBD has also been found to improve skin hydration and minimize moisture loss.
A few studies have also suggested that CBD may inhibit the growth of acne. Cannabinoid receptors found in the skin seem to be connected to the regulation of oil production in the sebaceous glands.9 We are developing cannabinoid-infused topical products to promote faster healing of damaged skin and to treat acne and other skin issues, such as psoriasis.
CBD can enter the body through various routes – the most studied are inhalation and orally. The route of administration determines the “bioavailability” of CBD, the proportion of the drug that enters circulation when introduced that is able to have an active effect.
Based on the observation that CBD is effective when inhaled, the bioavailability of CBD has been studied using devices to vaporize or aerosolize the substance. Using these methods, some studies have measured bioavailability of approximately 31% of the administered dose.15 Oral administration is an easier way to deliver CBD, but it suffers from a drawback that it must pass through the liver before entering systemic circulation, which introduces the risk that it will be broken down before it can have a therapeutic effect. With orally administered CBD, only 6% of the dose makes it through the liver unaltered.16
Given the drawbacks of current administration methods, there is clear potential for improved formulations and delivery methods that could increase the bioavailability of CBD while decreasing the production of undesirable metabolites. Zuux is developing proprietary formulations that utilize patented and patent-pending nano-encapsulation technologies to significantly improve the bioavailability profile of CBD and other cannabinoids.
Our current product formulations utilize a nano particle molecular transport mechanism to efficiently deliver orally administered CBD into the bloodstream and through the skin for topical applications. By utilizing microscopic spheres to carry active nutrients into our cells vastly increases the bioavailability and nutritional value of CBD. Since the actives are surrounded by a double-layer of lipids (fats) that closely resemble molecules of human cell membranes, they can be more readily absorbed into our bloodstream without triggering an immune response, therefore, eliminating the problem of wasted nutritional value common to most CBD products on the market today. Independent, third party testing shows that with only half the dose, a CBD product utilizing this technology exhibited absorption rates three times (300%) greater than a full dose of a standard CBD product.17
5Mohanraj Rajesh, PhD, Partha Mukhopadhyay, PhD, Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010 Dec 14; 56(25): 2115–2125.
7Sindiswa T. Lukhele and Lesetja R. Motadi. Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement Altern Med. 2016; 16(1): 335.
9Oláh A, Markovics A. Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Exp Dermatol. 2016 Sep;25(9):701-7.